Glycosaminoglycan composition changes with MG-63 osteosarcoma osteogenesis in vitro and induces human mesenchymal stem cell aggregation.

@article{Kumarasuriyar2009GlycosaminoglycanCC,
  title={Glycosaminoglycan composition changes with MG-63 osteosarcoma osteogenesis in vitro and induces human mesenchymal stem cell aggregation.},
  author={Arjuna Kumarasuriyar and Sadasivam Murali and Victor Nurcombe and Simon M Cool},
  journal={Journal of cellular physiology},
  year={2009},
  volume={218 3},
  pages={501-11}
}
Osteogenic differentiation is coordinated by the exposure of cells to temporal changes in a combination of growth factors and elements within the extracellular matrix (ECM). Many of the key proteins that drive these changes share the property of being dependent on ECM glycosaminoglycans (GAGs) for their activity. Here, we examined whether GAGs isolated from proliferating, differentiating and mineralizing MG-63 osteosarcoma cells differed in their physical properties, and thus in their… CONTINUE READING