Glycosaminoglycan Synthesis by Wilms' Tumor

  title={Glycosaminoglycan Synthesis by Wilms' Tumor},
  author={John J. Hopwood and Albert Dorfman},
  journal={Pediatric Research},
Summary: Wilms' tumor contains approximately 1 mg hyaluronic acid and approximately 0.3 mg sulfated glycosaminoglycan per g tissue. Minced tumor and cells cultured from the tumor incorporate labeled acetate and glucosamine into hyaluronic acid and sulfated glycosaminoglycans. A particulate enzyme preparation derived from the tumor catalyzed the transfer of GlcUA or GlcNAc from UDP-GlcUA or UDP-GlcNAc at a rate of approximately 20 nmol/hr/mg protein to produce high molecular weight hyaluronic… CONTINUE READING
14 Citations
32 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

Glycosaminoglycan synthesis in cultured simian virus 40 transformed human skin fibroblasts

  • J. J. Hopwood
  • Fed . Proc .
  • 1974

A tumorassociated antigen in human nephroblastomas

  • P. Burtin, C. Gendron.M.
  • Proc . Natl . Acad . Sci . U . S . A
  • 1973

Similar Papers

Loading similar papers…