Glycoproteomic characterization of butyrylcholinesterase from human plasma.

  title={Glycoproteomic characterization of butyrylcholinesterase from human plasma.},
  author={Daniel Kolarich and Alfred P. Weber and Martin Pabst and Johannes Stadlmann and Wolfgang Teschner and Hartmut J. Ehrlich and Hans-Peter Schwarz and Friedrich Altmann},
  volume={8 2},
Human butyrylcholinesterase (hBChE) is a highly glycosylated protein present in human plasma. The enzyme hydrolyses choline esters, for example benzoylcholine, butyrylthiocholine and acetylthiocholine as well as noncholine esters like heroin and aspirin. hBChE is primarily involved in neuronal transmission and is a potential bioscavenger of toxic organophosphates to protect acetylcholinesterase. A prerequisite for the therapeutic use of hBChE is a detailed characterization of this glycoprotein… CONTINUE READING