• Biology, Medicine
  • Published in
    Recent progress in hormone…
    1999

Glycoprotein hormone structure-function and analog design.

@article{Boime1999GlycoproteinHS,
  title={Glycoprotein hormone structure-function and analog design.},
  author={Irving Boime and David Ben-Menahem},
  journal={Recent progress in hormone research},
  year={1999},
  volume={54},
  pages={
          271-88; discussion 288-9
        }
}
Human chorionic gonadotropin (hCG), luteinizing hormone, follicle-stimulating hormone (FSH), and thyrotropin (TSH) are hormones that share a common alpha subunit but differ in their beta subunits. Recombinant DNA techniques, valuable tools for structure-function analyses, provide an approach for designing therapeutic analogs. FSH is used clinically to stimulate the ovarian follicles for in vitro fertilization and to initiate follicular maturation in women with infertility problems. The CG beta… CONTINUE READING

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