Glycoprotein hormone alpha-subunit-producing pituitary adenomas in rats treated for one year with calcitonin.

Abstract

Calcitonin, a calcium-lowering hormone, has been associated with an increased incidence of nonfunctioning pituitary tumors in rats. In this study, rats were treated with calcitonin (80 IU/kg/d) for 52 weeks. After treatment with calcitonin, immunohistochemistry and in situ hybridization analyses demonstrated that most pituitary tumors expressed the… (More)

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@article{Jameson1992GlycoproteinHA, title={Glycoprotein hormone alpha-subunit-producing pituitary adenomas in rats treated for one year with calcitonin.}, author={J. Larry Jameson and J. Weiss and Justyna Polak and Geniel Childs and S. R. Bloom and Jennifer H. Steel and Charles Chabert Capen and Dawn Prentice and A. W. Fetter and J M Langloss}, journal={The American journal of pathology}, year={1992}, volume={140 1}, pages={75-84} }