Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.

  title={Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.},
  author={L S Grinna and Phillips W. Robbins},
  journal={The Journal of biological chemistry},
  volume={254 18},
Asparagine-linked oligosaccharides of glycoproteins undergo extensive modification or "processing" following their attachment to protein. A key step in post-glycosylation processing is the sequential removal of glucose residues from the protein-linked oligosaccharide. We have studied rat liver preparations which catalyze removal of glucose from Glc3Man9GlcNAc, Glc2Man9GlcNAc, and Glc1Man9GlcNAc. Detergent solubilization studies, inhibitor studies, and temperature-activity profiles indicate that… CONTINUE READING

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