Glycoprotein-associated amino acid exchangers: broadening the range of transport specificity

@article{Verrey2000GlycoproteinassociatedAA,
  title={Glycoprotein-associated amino acid exchangers: broadening the range of transport specificity},
  author={François Verrey and Christian Meier and Gr{\'e}goire Rossier and Lukas C. K{\"u}hn},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={440},
  pages={503-512}
}
Members of the newly discovered glycoprotein-associated amino acid transporter family (gpaAT-family) share a similar primary structure with >40% identity, a predicted 12-transmembrane segment topology and the requirement for association with a glycoprotein (heavy chain) for functional surface expression. Five of the six identified gpaATs (light chains) associate with the surface antigen 4F2 heavy chain (4F2hc = CD98), a ubiquitous plasma membrane protein induced in cell proliferation, and which… CONTINUE READING

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