Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.

@article{Gibbins1997GlycoproteinVI,
  title={Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.},
  author={Jonathan M. Gibbins and Minoru Okuma and Richard W Farndale and Michael J. Barnes and Stephen P. Watson},
  journal={FEBS letters},
  year={1997},
  volume={413 2},
  pages={255-9}
}
We have recently shown that collagen activates platelets through a pathway dependent on the Fc receptor gamma-chain and the tyrosine kinase Syk. We report here that the Fc receptor gamma-chain and the candidate collagen receptor glycoprotein VI (GPVI) co-associate. Furthermore, cross-linking GPVI stimulates a similar pattern of tyrosine phosphorylation to that stimulated by collagen, including tyrosine phosphorylation of Fc receptor gamma-chain. These results support a model where GPVI couples… CONTINUE READING

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