Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not.

@article{Kehrel1998GlycoproteinVI,
  title={Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not.},
  author={Beate E. Kehrel and S L Wierwille and Kenneth J. Clemetson and O Anders and Marianne Steiner and C. Graham Knight and Richard W Farndale and Minoru Okuma and Michael J. Barnes},
  journal={Blood},
  year={1998},
  volume={91 2},
  pages={491-9}
}
Simple collagen-related peptides (CRPs) containing a repeat Gly-Pro-Hyp sequence are highly potent platelet agonists. Like collagen, they must exhibit tertiary (triple-helical) and quaternary (polymeric) structure to activate platelets. Platelet signaling events induced by the peptides are the same as most of those induced by collagen. The peptides do not recognize the alpha 2 beta 1 integrin. To identify the signaling receptor involved, we have evaluated the response to the CRP, Gly-Lys-Hyp… CONTINUE READING

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