Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.

@article{Nieswandt2001GlycoproteinVB,
  title={Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.},
  author={Bernhard Nieswandt and Cord Brakebusch and Wolfgang Bergmeier and Valerie Schulte and Daniel Bouvard and Rab{\'e}e Mokhtari-Nejad and Theo Lindhout and Johan W. M. Heemskerk and Hubert Zirngibl and Reinhard F{\"a}ssler},
  journal={The EMBO journal},
  year={2001},
  volume={20 9},
  pages={2120-30}
}
Platelet adhesion on and activation by components of the extracellular matrix are crucial to arrest post-traumatic bleeding, but can also harm tissue by occluding diseased vessels. Integrin alpha2beta1 is thought to be essential for platelet adhesion to subendothelial collagens, facilitating subsequent interactions with the activating platelet collagen receptor, glycoprotein VI (GPVI). Here we show that Cre/loxP-mediated loss of beta1 integrin on platelets has no significant effect on the… CONTINUE READING

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