Glycoprotein VI agonists have distinct dependences on the lipid raft environment.

  title={Glycoprotein VI agonists have distinct dependences on the lipid raft environment.},
  author={Patricia G Quinter and Carol A Dangelmaier and Todd M. Quinton and Satya P Kunapuli and James L. Daniel},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={5 2},
BACKGROUND It has been reported that the association of glycoprotein VI (GPVI) with lipid rafts regulates GPVI signaling in platelets. OBJECTIVE Secreted adenosine 5'-diphosphate (ADP) potentiates GPVI-induced platelet aggregation at particular agonist concentrations. We have investigated whether the decrease in GPVI signaling, previously reported in platelets with disrupted rafts, is a result of the loss of agonist potentiation by ADP. METHODS We disrupted platelet lipid rafts with methyl… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…