Glycoprotein Quality Control and Endoplasmic Reticulum Stress.

  title={Glycoprotein Quality Control and Endoplasmic Reticulum Stress.},
  author={Qian Wang and Jody Groenendyk and Marek Michalak},
  volume={20 8},
The endoplasmic reticulum (ER) supports many cellular processes and performs diverse functions, including protein synthesis, translocation across the membrane, integration into the membrane, folding, and posttranslational modifications including N-linked glycosylation; and regulation of Ca2+ homeostasis. In mammalian systems, the majority of proteins synthesized by the rough ER have N-linked glycans critical for protein maturation. The N-linked glycan is used as a quality control signal in the… CONTINUE READING
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