Glycoprotein Ib-IX-V.

  title={Glycoprotein Ib-IX-V.},
  author={Robert K Andrews and Elizabeth E Gardiner and Yang Shen and James C. Whisstock and Michael C. Berndt},
  journal={The international journal of biochemistry & cell biology},
  volume={35 8},
Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, alphaMbeta2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells… CONTINUE READING

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