Glycoprotein Ib ( GP 1 b )-Dependent and GPIb-Independent Pathways of Thrombin-Induced Platelet Activation

@inproceedings{Yamamoto2003GlycoproteinI,
  title={Glycoprotein Ib ( GP 1 b )-Dependent and GPIb-Independent Pathways of Thrombin-Induced Platelet Activation},
  author={Naomasa Yamamoto and Nicholas J. Greco and Marc R. Barnard and Kenjiro Tanoue and Yamazaki and Graham A Jamieson and Alan D Michelson},
  year={2003}
}
In this study, the question of whether glycoprotein Ib (GPlb) mediates both high and moderate affinity pathways of a-thrombin-induced platelet activation was examined. Flow cytometric studies, using a panel of monoclonal antibodies (MoAbs), showed that Serratia marcescens protease treatment removed greater than 97% of the glycocalicin portion of GPlb but did not affect the changes in the expression of GPIX or GMP-140 that were induced by high concentrations of a-thrombin ( I O nmol/L). However… CONTINUE READING