Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.

@article{Silverstein1989GlycoproteinIM,
  title={Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.},
  author={Roy L Silverstein and Adam S. Asch and Ralph L. Nachman},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={84 2},
  pages={
          546-52
        }
}
An adhesive interaction between activated platelets and mononuclear phagocytes may contribute to the role these cells play in regulating inflammation, thrombosis, and atherosclerosis. We have previously shown that this adhesive interaction is mediated by the expression of the glycoprotein thrombospondin (TSP) on the surface of activated platelets. We now show that TSP-dependent platelet-monocyte interactions are mediated by glycoprotein IV (GPIV), an intrinsic membrane protein recently… CONTINUE READING
Highly Cited
This paper has 79 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

CD36 deficiency predisposing young children to fasting hypoglycemia.

Metabolism: clinical and experimental • 2011
View 2 Excerpts

79 Citations

05'90'96'03'10'17
Citations per Year
Semantic Scholar estimates that this publication has 79 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 24 references

An integrin on normal and thrombasthenic platelets which binds thrombospondin

R. L. Silverstein, L. L. K. Leung, R. L. Nachman
Blood . • 1988

Isolation of the thrombospondin membrane receptor

P. C. Harpel, R. L. Nachman
J . Clin . Invest . • 1987

Thrombo - spondin promotes cell - substratum adhesion

J. Lawler
Science ( Wash . DC ) . • 1987

The structure of human thrombospondin , an adhesion glycoprotein with multiple calcium - binding sites and homology with several different proteins

M. D. Pierschbacher, E. Rouslahti
J . Cell Biol . • 1986