Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B.

@article{Herold1994GlycoproteinCB,
  title={Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B.},
  author={Betsy C. Herold and Robert J Visalli and N Susmarski and Curtis R. Brandt and Patricia G. Spear},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 6)},
  pages={1211-22}
}
Previous studies have shown that the initial interaction of herpes simplex virus (HSV) with cells is binding to heparan sulphate and that HSV-1 glycoprotein C (gC) is principally responsible for this binding. Although gC-negative viral mutants are impaired for binding and entry, they retain significant infectivity. The purpose of the studies reported here was to explore the requirements for infectivity of gC-negative HSV-1 mutants. We found that absence or alteration of cell surface heparan… CONTINUE READING
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