Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis.

@article{Huang2012Glycoprotein9P,
  title={Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis.},
  author={Qi Huang and Renee E Koessler and Robert Birkett and Andrea Dorfleutner and Harris Perlman and G. Kenneth Haines and Christian Stehlik and Christopher V Nicchitta and Richard M. Pope},
  journal={Arthritis and rheumatism},
  year={2012},
  volume={64 11},
  pages={3638-48}
}
OBJECTIVE The mechanisms that contribute to the persistent activation of macrophages in rheumatoid arthritis (RA) are incompletely understood. The aim of this study was to determine the contribution of endogenous gp96 in Toll-like receptor (TLR)-mediated macrophage activation in RA. METHODS RA synovial fluid was used to activate macrophages and HEK-TLR-2… CONTINUE READING