Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.

@article{Sims2004Glycoprotein1R,
  title={Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.},
  author={Natalie A Sims and Brendan J Jenkins and Julian M. W. Quinn and Akira Nakamura and Markus Glatt and Matthew T. Gillespie and Matthias Ernst and Thomas J Martin},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 3},
  pages={379-89}
}
The gp130-dependent cytokines, which signal through at least two intracellular pathways, regulate osteoclast and osteoblast formation. To define their roles in regulating bone mass, we analyzed mice in which gp130 signaling via either the signal transducer and activator of transcription (STAT) 1/3 (gp130(DeltaSTAT/DeltaSTAT)) or SHP2/ras/MAPK (gp130(Y757F/Y757F)) pathway was attenuated. In gp130(DeltaSTAT/DeltaSTAT) mice, trabecular bone volume (BV/TV) and turnover were normal, but bone length… CONTINUE READING