Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.

  title={Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.},
  author={Sander I van Kasteren and Sandra J. Campbell and S{\'e}bastien Serres and Daniel C. Anthony and Nicola R. Sibson and Benjamin G Davis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 1},
Initial recruitment of leukocytes in inflammation associated with diseases such as multiple sclerosis (MS), ischemic stroke, and HIV-related dementia, takes place across intact, but activated brain endothelium. It is therefore undetectable to symptom-based diagnoses and cannot be observed by conventional imaging techniques, which rely on increased permeability of the blood-brain barrier (BBB) in later stages of disease. Specific visualization of the early-activated cerebral endothelium would… CONTINUE READING
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