Glycolytic strategy as a tradeoff between energy yield and protein cost.

@article{Flamholz2013GlycolyticSA,
  title={Glycolytic strategy as a tradeoff between energy yield and protein cost.},
  author={Avi I. Flamholz and Elad Noor and Arren Bar-Even and Wolfram Liebermeister and Ron Milo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 24},
  pages={10039-44}
}
Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all domains of life, not all sugar-consuming organisms use the canonical Embden-Meyerhoff-Parnass (EMP) glycolytic pathway. Prokaryotic glucose metabolism is particularly diverse, including several alternative glycolytic pathways, the most common of which is the Entner-Doudoroff (ED) pathway. The prevalence of the ED pathway is puzzling as it produces only one ATP per glucose--half as much as the EMP pathway… CONTINUE READING
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