Glycolytic reliance promotes anabolism in photoreceptors

  title={Glycolytic reliance promotes anabolism in photoreceptors},
  author={Yashodhan Chinchore and Tedi Begaj and David Wu and Eugene Drokhlyansky and Constance L. Cepko},
Vertebrate photoreceptors are among the most metabolically active cells, exhibiting a high rate of ATP consumption. This is coupled with a high anabolic demand, necessitated by the diurnal turnover of a specialized membrane-rich organelle, the outer segment, which is the primary site of phototransduction. How photoreceptors balance their catabolic and anabolic demands is poorly understood. Here, we show that rod photoreceptors in mice rely on glycolysis for their outer segment biogenesis… CONTINUE READING
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