Glycolytic inhibition as a strategy for developing calorie restriction mimetics

@article{Ingram2011GlycolyticIA,
  title={Glycolytic inhibition as a strategy for developing calorie restriction mimetics},
  author={Donald K Ingram and George S. Roth},
  journal={Experimental Gerontology},
  year={2011},
  volume={46},
  pages={148-154}
}

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References

SHOWING 1-10 OF 113 REFERENCES

Caloric Restriction Mimetics: The Next Phase

TLDR
The next phase of calorie restriction studies includes basic investigations as well as possible clinical trials of a number of candidate CR mimetics, ranging from glycolytic inhibitors to lipid‐regulating agents to antioxidants and specific gene modulators.

Calorie restriction mimetics: an emerging research field

TLDR
New research has focused on the development of ‘CR mimetics’, which is to identify compounds that mimic CR effects by targeting metabolic and stress response pathways affected by CR, but without actually restricting caloric intake.

Progress in the Development of Caloric Restriction Mimetic Dietary Supplements

TLDR
The initial findings reviewed here suggest a novel approach for the investigation of basic mechanisms of aging, in which cells upregulate heat-shock and other chaperone proteins, and growth factors.

Toward a unified theory of caloric restriction and longevity regulation

  • D. Sinclair
  • Biology
    Mechanisms of Ageing and Development
  • 2005

SIR2: a potential target for calorie restriction mimetics.

Identification of potential caloric restriction mimetics by microarray profiling.

TLDR
Results indicate that gene expression biomarkers can be used to identify promising candidate CR mimetics, and metformin has been shown to reduce cancer incidence in mice and humans.

SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.

TLDR
This review summarizes current understanding of the biological functions of SIRT1, and discusses its potential as a pharmacological target for fighting metabolic and vascular diseases.

2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction

TLDR
Results from CR studies in rhesus monkeys agree with the extensive rodent literature that suggests this intervention can have beneficial effects in primates, and it is unlikely that the 30% to 40% reduction in intake used typically in this paradigm would become a widespread practice in humans.

Resveratrol, sirtuins, and the promise of a DR mimetic

  • J. Baur
  • Biology
    Mechanisms of Ageing and Development
  • 2010

Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats.

...