Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.

@article{Lee2009GlycolyticFS,
  title={Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.},
  author={Mi Nam Lee and Sang Hoon Ha and Jaeyoon Kim and Ara Koh and Chang Sup Lee and Jung Hwan Kim and Hyeona Jeon and Do-Hyung Kim and Pann Ghill Suh and Sung Ho Ryu},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 14},
  pages={3991-4001}
}
The mammalian target of rapamycin (mTOR) interacts with raptor to form the protein complex mTORC1 (mTOR complex 1), which plays a central role in the regulation of cell growth in response to environmental cues. Given that glucose is a primary fuel source and a biosynthetic precursor, how mTORC1 signaling is coordinated with glucose metabolism has been an important question. Here, we found that the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) binds Rheb and inhibits mTORC1… CONTINUE READING
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