Glycolysis in cancer: a potential target for therapy.

  title={Glycolysis in cancer: a potential target for therapy.},
  author={Robert A. Gatenby and Robert J. Gillies},
  journal={The international journal of biochemistry & cell biology},
  volume={39 7-8},
Clinical imaging of primary and metastatic cancers with Fluoro deoxy-d-Glucose Positron Emission Tomography (FdG PET) has clearly demonstrated that increased glucose flux compared to normal tissue is a common trait of human malignancies (Gambhir, 2002) This is a consequence of a shift of glucose metabolism to less efficient glycolytic pathways in response to regional hypoxia and evolution of aerobic glycolysis in many cancer phenotypes. This distinctive metabolic profile presents an inviting… CONTINUE READING

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