Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.

@article{Bakker1997GlycolysisIB,
  title={Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.},
  author={Barbara M. Bakker and Paul A. M. Michels and Fred R. Opperdoes and Hans V. Westerhoff},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 6},
  pages={3207-15}
}
In trypanosomes the first part of glycolysis takes place in specialized microbodies, the glycosomes. Most glycolytic enzymes of Trypanosoma brucei have been purified and characterized kinetically. In this paper a mathematical model of glycolysis in the bloodstream form of this organism is developed on the basis of all available kinetic data. The fluxes and the cytosolic metabolite concentrations as predicted by the model were in accordance with available data as measured in non-growing… CONTINUE READING

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