Glycolysis and pyruvate oxidation in cardiac hypertrophy--why so unbalanced?

@article{Leong2003GlycolysisAP,
  title={Glycolysis and pyruvate oxidation in cardiac hypertrophy--why so unbalanced?},
  author={Hon S Leong and Roger W. Brownsey and Jerzy E. Kulpa and Michael F. Allard},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2003},
  volume={135 4},
  pages={499-513}
}
Cardiac hypertrophy, induced by chronic pressure or volume overload, is associated with abnormalities in energy metabolism as well as characteristic increases in muscle mass and alterations in the structure of the heart. Hypertrophied hearts display increased rates of glycolysis and overall glucose utilization, but rates of pyruvate oxidation do not rise in… CONTINUE READING