Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

@inproceedings{Alfarouk2014GlycolysisTM,
  title={Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question},
  author={Khalid Omer Alfarouk and Daniel Verduzco and Cyril Rauch and Abdel Khalig Muddathir and Adil H. H. Bashir and Gamal O. Elhassan and Muntasir Eltayeb Ibrahim and Julian David Polo Orozco and Rosa Angela Cardone and Stephan Joel Reshkin and Salvador Harguindey},
  booktitle={Oncoscience},
  year={2014}
}
Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their intracellular alkaline pH (pHi). This effect is part of the metabolic alterations found in most, if not all, cancer cells to deal with unfavorable conditions, mainly hypoxia and low nutrient supply, in order to preserve its evolutionary trajectory with the production of lactate after ten steps of glycolysis. Thus, cancer cells reprogram their cellular metabolism in a way that gives them their evolutionary… CONTINUE READING
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