Glycolipids as immunostimulating agents.

  title={Glycolipids as immunostimulating agents.},
  author={Douglass Wu and Masakazu Fujio and C. -H. Wong},
  journal={Bioorganic & medicinal chemistry},
  volume={16 3},
The processing and presentation of lipid antigens by antigen presenting cells (APC) is important for defense against infection, tumor immunosurveillance, and autoimmunity. CD1, a family of cell surface glycoproteins, is responsible for the binding and presentation of lipid antigens to receptors expressed on the surface of T lymphocytes. Among the several (glyco)lipids identified to cause T-cell stimulation in complex with CD1, alpha-galactosyl ceramide (alpha-GalCer) is one of the most well… CONTINUE READING
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