Glycolipid-anchored form of CD4 increases intercellular adhesion but is unable to enhance T cell activation.

@article{Sleckman1991GlycolipidanchoredFO,
  title={Glycolipid-anchored form of CD4 increases intercellular adhesion but is unable to enhance T cell activation.},
  author={Barry P Sleckman and Yvonne J. Rosenstein and Vivien E. Igras and Julia L. Greenstein and S J Burakoff},
  journal={Journal of immunology},
  year={1991},
  volume={147 2},
  pages={428-31}
}
CD4 functions to enhance T cell activation by increasing intercellular adhesion and/or by transduction of an intracellular signal. To study the role of human CD4 in T cell activation we have used a murine T cell hybridoma, By 155.16, which produces IL-2 when stimulated by HLA-DR-bearing cells. Previously, we have shown that expression of human CD4 by this hybridoma enhances its ability to produce IL-2 in response to HLA-DR-bearing cells. Furthermore, deletion of the majority of the cytoplasmic… CONTINUE READING

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