Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group.

@article{Moreau1998GlycolateKA,
  title={Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group.},
  author={Caroline Moreau and William Kerns and Christian A. Tomaszewski and Kenneth E. McMartin and Susan R Rose and Marsha D Ford and Jeffrey Brent},
  journal={Journal of toxicology. Clinical toxicology},
  year={1998},
  volume={36 7},
  pages={659-66}
}
OBJECTIVE Toxic manifestations following ethylene glycol exposure are due to accumulation of metabolites, particularly glycolate. We characterized glycolate elimination kinetics and dialysis properties in a series of ethylene glycol poisonings. METHODS Patients who ingested ethylene glycol and received fomepizole (4-methylpyrazole; 4-MP) +/- hemodialysis were prospectively evaluated. Serial blood samples for ethylene glycol, glycolate, pH, and bicarbonate were drawn to determine glycolate… CONTINUE READING
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