Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties.

@article{Nielsen1988GlycolamideEA,
  title={Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties.},
  author={Nete Munk Nielsen and Hans Bundgaard},
  journal={Journal of pharmaceutical sciences},
  year={1988},
  volume={77 4},
  pages={285-98}
}
Benzoic acid esters of various substituted 2-hydroxyacetamides (glycolamides) were found to be hydrolyzed extremely rapidly in human plasma solutions, the half-lives of hydrolysis being less than 5 s in 50% plasma solutions for some N,N-disubstituted glycolamide esters. The rapid rate of hydrolysis could be largely attributed to cholinesterase (also called… CONTINUE READING