Glycolaldehyde causes DNA-protein crosslinks: a new aspect of ethylene oxide genotoxicity.

Abstract

After in vitro incubation of human peripheral mononuclear blood cells with glycolaldehyde (a putative metabolite of ethylene oxide) for 2 h at 37 degrees C, a dose-dependent increase in DNA crosslinks was observed in a dose range between 1 and 10 mM using the alkaline filter elution technique. The elution rate of mononuclear blood cells after treatment with… (More)

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@article{Hengstler1994GlycolaldehydeCD, title={Glycolaldehyde causes DNA-protein crosslinks: a new aspect of ethylene oxide genotoxicity.}, author={J. G. Hengstler and J. Fuchs and Susanne Gebhard and Franz Oesch}, journal={Mutation research}, year={1994}, volume={304 2}, pages={229-34} }