Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1.

@article{Seimi2004GlycogenSK,
  title={Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1.},
  author={Satomi-Kobayashi Seimi and Kawashima Seinosuke and Sakoda Tsuyoshi and Ueyama Tomomi and Hirase Tetsuaki and Kawai Miki and Toh Ryuji and Iwai Kenji and Yokoyama Mitsuhiro},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2004},
  volume={68 3},
  pages={247-53}
}
BACKGROUND Glycogen synthase kinase-3 beta (GSK-3beta) is involved in many cellular processes, such as metabolism, apoptosis, differentiation and proliferation. Insulin-like growth factor-1 (IGF-1), which is well known to have a hypertrophic effect on cardiomyocytes, inactivates (phosphorylates) GSK-3beta in some cell types. The role of GSK-3beta in cardiomyocytes as a negative regulator of cardiac hypertrophy has been recently reported and the present study investigated the role of GSK-3beta… CONTINUE READING
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