Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization.

@article{Li2008GlycogenSK,
  title={Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization.},
  author={Jiansha Li and Mingyou Xing and Min Zhu and Xi Wang and Manxiang Wang and Sheng Zhou and Naping Li and Renliang Wu and Muxiang Zhou},
  journal={Cancer letters},
  year={2008},
  volume={272 1},
  pages={91-101}
}
Glycogen synthase kinase 3beta (GSK3beta) regulates numerous signaling pathways that control a wide range of cellular processes, including cell proliferation, differentiation, apoptosis and metabolism. We report a novel function of GSK3beta: It interacts with the inhibitor-of-apoptosis protein (IAP) survivin to modulate its expression, thus regulating apoptosis in human lung cancer cells. A co-immunoprecipitation assay revealed that GSK3beta can bind survivin. Activation of GSK3beta induced… CONTINUE READING

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