Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization.

@article{Xu2009GlycogenSK,
  title={Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization.},
  author={Chun-mei Xu and Jun Wang and Ping Wu and Wei-li Zhu and Qian-qian Li and Yan-xue Xue and Hai-fen Zhai and Jie Shi and Lin Lu},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 6},
  pages={1357-68}
}
Glycogen synthase kinase 3beta (GSK-3beta) is a ubiquitous serine/threonine protein kinase involved in a number of signaling pathways. Previous studies have demonstrated a role for GSK-3beta in the synaptic plasticity underlying dopamine-associated behaviors and diseases. Drug sensitization is produced by repeated exposure to the drug and is thought to reflect neuroadaptations that contribute to addiction. However, the role of GSK-3beta in cocaine-induced behavior sensitization has not been… CONTINUE READING

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