Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer.

@article{Liao2004GlycogenSK,
  title={Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer.},
  author={Xinbo Liao and James Brantley Thrasher and Jeffery M. Holzbeierlein and Scott D. Stanley and Benyi Li},
  journal={Endocrinology},
  year={2004},
  volume={145 6},
  pages={
          2941-9
        }
}
Despite the specificity inferred by its name, glycogen synthase kinase (GSK)-3beta is an important kinase with a plethora of significant cellular targets, including cytoskeletal proteins and transcription factors, and its activity is regulated by phosphorylation on tyrosine/serine residues. As part of our efforts to dissect the molecular basis responsible for androgen-independent progression of prostate cancer, we investigated the role of GSK-3beta in androgen-stimulated gene expression in… CONTINUE READING

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