Glycogen synthase kinase 3 promotes p 53 mRNA translation via phosphorylation of RNPC 1

@inproceedings{Zhang2013GlycogenSK,
  title={Glycogen synthase kinase 3 promotes p 53 mRNA translation via phosphorylation of RNPC 1},
  author={Min Zhang and Jin Zhang and Xiangling Chen and Seong-Jun Cho and Xinbin Chen},
  year={2013}
}
The RNPC1 RNA-binding protein, also called Rbm38, is a target of p53 and a repressor of p53 mRNA translation. Thus, the p53–RNPC1 loop is critical for modulating p53 tumor suppression, but it is not clear how the loop is regulated. Here, we showed that RNPC1 is phosphorylated at Ser195 by glycogen synthase kinase 3 (GSK3). We also showed that GSK3 promotes p53 mRNA translation through phosphorylation of RNPC1. Interestingly, we found that the phosphor-mimetic mutant S195D and the deletion… CONTINUE READING

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