Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein.

@article{Parr2012GlycogenSK,
  title={Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein.},
  author={Callum Parr and Raffaela Carzaniga and S M Gentleman and Fred van Leuven and Jochen Walter and M. A. Rodr{\'i}guez Sastre},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 21},
  pages={
          4410-8
        }
}
Alzheimer's disease (AD) has been associated with altered activity of glycogen synthase kinase 3 (GSK3) isozymes, which are proposed to contribute to both neurofibrillary tangles and amyloid plaque formation. However, the molecular basis by which GSK3 affects the formation of Aβ remains unknown. Our aim was to identify the underlying mechanisms of GSK3-dependent effects on the processing of amyloid precursor protein (APP). For this purpose, N2a cells stably expressing APP carrying the Swedish… CONTINUE READING
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