Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.

  title={Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.},
  author={Francesca Demarchi and Cosetta Bertoli and Peter Sandy and Claudio Schneider},
  journal={The Journal of biological chemistry},
  volume={278 41},
A number of different kinases have been implicated in NF-kappa B regulation and survival function. Here we investigated the molecular cross-talk between glycogen synthase kinase-3 beta (GSK-3 beta) and the p105 precursor of the NF-kappa B p50 subunit. GSK-3 beta forms an in vivo complex with and specifically phosphorylates NF-kappa B1/p105 at Ser-903 and Ser-907 in vitro. In addition, the p105 phosphorylation level is reduced in fibroblasts lacking GSK-3 beta as compared with wild-type cells… CONTINUE READING
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