Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.

@article{Lee2003GlycogenSK,
  title={Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.},
  author={Chris Wing-Cheung Lee and K F Lau and Christopher J Miller and P S Shaw},
  journal={Neuroreport},
  year={2003},
  volume={14 2},
  pages={257-60}
}
To study further the role of glycogen synthase kinase-3beta on tau phosphorylation, glycogen synthase kinase-3beta and tau expression vectors were co-transfected into CHO-K1, COS-7 and SH-SY5Y cell. Tau phosphorylation was assessed by phosphorylation-dependent antibodies AT-8, AT-180, AT-270 and PHF-1. The AT-270 and AT-8 epitopes were consistently phosphorylated by glycogen synthase kinase-3beta in the three cell lines. Phosphorylation on AT-180 epitope was significant in CHO-K1 and SH-SY5Y… CONTINUE READING

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