Glycogen synthase kinase-3 and leukemia: restoring the balance.

@article{Birch2010GlycogenSK,
  title={Glycogen synthase kinase-3 and leukemia: restoring the balance.},
  author={Noah Warren Birch and Nancy J. Zeleznik-Le},
  journal={Cancer cell},
  year={2010},
  volume={17 6},
  pages={
          529-31
        }
}
The role of GSK-3 in oncogenesis is paradoxical, acting as a tumor suppressor in some cancers and potentiating growth in others. In this issue of Cancer Cell, Wang et al. provide some mechanistic insight into GSK-3 activity's role in potentiating leukemias which are dependent on homeobox (HOX) gene misregulation. 
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