Glycogen synthase kinase-3 and cancer: good cop, bad cop?

@article{Patel2008GlycogenSK,
  title={Glycogen synthase kinase-3 and cancer: good cop, bad cop?},
  author={Satish Patel and Jim Woodgett},
  journal={Cancer cell},
  year={2008},
  volume={14 5},
  pages={351-3}
}
Dogma held that inhibition of the pleiotropic protein kinase glycogen synthase kinase-3 (GSK-3) was procarcinogenic due to its natural repression of beta-catenin. Now, Wang et al. have found the reverse in certain leukemias, possibly paving the way for small-molecule GSK-3 inhibitors as selective anticancer agents. 

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