Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions.

@article{Jope2006GlycogenSK,
  title={Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions.},
  author={Richard Scott Jope and M Roh},
  journal={Current drug targets},
  year={2006},
  volume={7 11},
  pages={
          1421-34
        }
}
Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with these diseases. GSK3 is a widely influential enzyme that is capable of phosphorylating, and thereby regulating, over forty known substrates. Four mechanisms regulating GSK3 (phosphorylation, protein complexes, localization, and substrate phosphorylation) combine to provide substrate-specific regulation of the actions of GSK3… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 141 extracted citations

Similar Papers

Loading similar papers…