Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions.

  title={Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions.},
  author={Richard Scott Jope and M Roh},
  journal={Current drug targets},
  volume={7 11},
Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with these diseases. GSK3 is a widely influential enzyme that is capable of phosphorylating, and thereby regulating, over forty known substrates. Four mechanisms regulating GSK3 (phosphorylation, protein complexes, localization, and substrate phosphorylation) combine to provide substrate-specific regulation of the actions of GSK3… CONTINUE READING
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