Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.

@article{Hamann2007GlycogenSK,
  title={Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.},
  author={Mark T. Hamann and Diana G Alonso and Ester Mart{\'i}n-Aparicio and Ana Fuertes and M Jos{\'e} P{\'e}rez-Puerto and Ana M. Jerez Castro and Susana R. Morales and Mar{\'i}a Luisa Navarro and Mar{\'i}a del Monte-Mill{\'a}n and Miguel Medina and Hari Kishore Pennaka and Akula Balaiah and Jiangnan Peng and Jennifer Cook and Subagus Wahyuono and Ana Mercedes Victoria Mart{\'i}nez},
  journal={Journal of natural products},
  year={2007},
  volume={70 9},
  pages={1397-405}
}
Manzamine A and related derivatives isolated from a common Indonesian sponge, Acanthostrongylophora, have been identified as a new class of GSK-3beta inhibitors. The semisynthesis of new analogues and the first structure-activity relationship studies with GSK-3beta are also reported. Moreover, manzamine A proved to be effective in decreasing tau hyperphosphorylation in human neuroblastoma cell lines, a demonstration of its ability to enter cells and interfere with tau pathology. Inhibition… CONTINUE READING

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