Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.

@article{Chikano2015GlycogenSK,
  title={Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.},
  author={Yuri Chikano and Takahiro Domoto and Takuya Furuta and Hemragul Sabit and Ayako Kitano-Tamura and Ilya V. Pyko and Takahisa Takino and Y. Shanmukh Sai and Yutaka Hayashi and Hiroshi Sato and Ken-Ichi Miyamoto and Mitsutoshi Nakada and Toshinari Minamoto},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 2},
  pages={
          564-74
        }
}
The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer. We previously reported that inhibition of GSK3β compromises the survival and proliferation of glioblastoma cells, induces their apoptosis, and sensitizes them to temozolomide and radiation. Here, we… CONTINUE READING

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