Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation.

@article{Rom2012GlycogenSK,
  title={Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation.},
  author={Slava Rom and Shongshan Fan and Nancy L. Reichenbach and Holly Dykstra and Servio H. Ramirez and Yuri Persidsky},
  journal={The American journal of pathology},
  year={2012},
  volume={181 4},
  pages={1414-25}
}
Glycogen synthase kinase (GSK) 3β has been identified as a regulator of immune responses. We demonstrated previously that GSK3β inhibition in human brain microvascular endothelial cells (BMVECs) reduced monocyte adhesion/migration across BMVEC monolayers. Herein, we tested the idea that GSK3β inhibition in monocytes can diminish their ability to engage the brain endothelium and migrate across the blood-brain barrier. Pretreatment of primary monocytes with GSK3β inhibitors resulted in a decrease… CONTINUE READING

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