Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death.

@article{Lal2012GlycogenSK,
  title={Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death.},
  author={Hind Lal and J Zhou and Firdos Ahmad and Raihana Zaka and Ronald J. Vagnozzi and Morgan Decaul and James R Woodgett and Erhe Gao and Thomas L. Force},
  journal={Circulation},
  year={2012},
  volume={125 1},
  pages={65-75}
}
BACKGROUND The molecular pathways that regulate the extent of ischemic injury and post-myocardial infarction (MI) remodeling are not well understood. We recently demonstrated that glycogen synthase kinase-3α (GSK-3α) is critical to the heart's response to pressure overload. However, the role, if any, of GSK-3α in regulating ischemic injury and its consequences is not known. METHODS AND RESULTS MI was induced in wild-type (WT) versus GSK-3α((-/-)) (KO) littermates by left anterior descending… CONTINUE READING