Glycogen synthase kinase-3&bgr; is highly activated in nuclei and mitochondria

  title={Glycogen synthase kinase-3\&bgr; is highly activated in nuclei and mitochondria},
  author={Gautam N. Bijur and Richard Scott Jope},
  • G. Bijur, R. Jope
  • Published 19 December 2003
  • Biology, Computer Science
  • NeuroReport
Glycogen synthase kinase-3&bgr; (GSK3&bgr;) is located predominantly in the cytosol, but also is in nuclei and mitochondria. In SH-SY5Y cells, primary cortical neurons, and mouse brain, the portion of active GSK3&bgr; (not phosphorylated on serine-9) was 5- to 8-fold greater in nuclei and mitochondria than in cytosol. Correspondingly greater GSK3&bgr; activities were measured in nuclei and mitochondria compared with cytosol. Stimulation of apoptotic signaling by treatment with camptothecin or… 
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