Glycogen phosphorylase inhibitors: a patent review (2008 - 2012).

  title={Glycogen phosphorylase inhibitors: a patent review (2008 - 2012).},
  author={Nicolas Gaboriaud-Kolar and A L Skaltsounis},
  journal={Expert opinion on therapeutic patents},
  volume={23 8},
INTRODUCTION Glycogen phosphorylase (GP) is the enzyme responsible for the synthesis of glucose-1-phosphate, the source of energy for muscles and the rest of the body. The binding of different ligands in catalytic or allosteric sites assures activation and deactivation of the enzyme. A description of the regulation mechanism and the implications in glycogen metabolism are given. AREAS COVERED Deregulation of GP has been observed in diseases such as diabetes mellitus or cancers. Therefore, it… CONTINUE READING
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