Glycoconjugated hypocrellin: synthesis of [(beta-D-glucosyl)ethylthiyl]hypocrellins and photosensitized generation of singlet oxygen.


In order to improve the water solubility and specific affinity for malignant tumors of hypocrellin, glycoconjugated hypocrellins have been synthesized using an improved Königs-Knörr reaction from mercaptoethanol substituted hypocrellin B and 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide precursors. Deprotection of glucose moieties allows the… (More)


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